HitPredict

Interactor 1: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Interactor 2: UBP20 (Q9Y2K6)
Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)
Gene: USP20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 914
+	Hs
		1257024 EPAS1_HUMAN (1-870): 0: 863: 100.00		UBP33_HUMAN (1-914): 0: 803: 57.96
+	Hs
		1085729 HIF1A_HUMAN (3-868): 0: 553: 42.32		UBP20_HUMAN (1-914): 0: 865: 100.00
+	Hs
		1121190 EPAS1_HUMAN (1-870): 0: 863: 100.00		UBP39_HUMAN (566-693): 1.67e-36: 148: 27.69
+	Hs
		777070 EPAS1_HUMAN (1-870): 0: 863: 100.00		UBP8_HUMAN (143-249): 1.16e-11: 70.9: 37.17
+	Hs
		1085708 HIF1A_HUMAN (3-868): 0: 553: 42.32		UBP25_HUMAN (128-818): 2.76e-71: 257: 12.71
+	Hs
		1085724 HIF1A_HUMAN (3-868): 0: 553: 42.32		UBP22_HUMAN (240-688): 4.25e-56: 204: 18.52
+	Hs
		301402 HIF1A_HUMAN (3-868): 0: 553: 42.32		UBP19_HUMAN (85-409): 1.12e-43: 174: 18.21
+	Hs
		1024405 NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12		UBP4_HUMAN (105-715): 1.25e-110: 365: 18.14
+	Hs
		777046 HIF1A_HUMAN (3-868): 0: 553: 42.32		UBP8_HUMAN (143-249): 1.16e-11: 70.9: 37.17
+	Mm
		292026 BMAL1_MOUSE (1-524): 1.34e-131: 409: 20.91		UBP2_MOUSE (89-269): 2.79e-42: 166: 25.41
+	Dm
		247722 CLOCK_DROME (16-651): 1.88e-96: 326: 16.62		Q9VDD8_DROME (94-248): 3.95e-36: 149: 29.09