Interactor 1: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Interactor 2: DERL1 (Q9BUN8)
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Gene: DERL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.686

The method score is based on:

Property Details
Experiments 36074076, 24019521, 16901789, 21594788
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0031648 - protein destabilization
GO:0036503 - ERAD pathway
GO:0044877 - protein-containing complex binding
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 180
Hs

1 251
+ Hs
+ Hs
+ Dm
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024