HitPredict

Interactor 1: PKP2 (Q99959)
Plakophilin-2
Gene: PKP2

Interactor 2: AKAP9 (Q99996)
A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)
Gene: AKAP9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	30217970
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0044325 - transmembrane transporter binding GO:0060090 - molecular adaptor activity GO:0086091 - regulation of heart rate by cardiac conduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 881 Hs			1 3907
+	Hs
		1307369 PKP2_HUMAN (1-881): 0: 726: 100.00		CP250_HUMAN (2-1330): 1.53e-46: 189: 10.71
+	Hs
		149216 PKP2_HUMAN (1-881): 0: 726: 100.00		CTRO_HUMAN (18-648): 1.78e-09: 66.5: 12.83
+	Hs
		551819 PKP2_HUMAN (1-881): 0: 726: 100.00		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94
+	Mm
		970212 PLAK_MOUSE (224-861): 3.4e-130: 409: 15.52		CE290_MOUSE (1750-3892): 3.91e-53: 210: 9.27
+	Hs
		626242 APC_HUMAN (24-771): 1.07e-107: 368: 14.78		CP250_HUMAN (2-1330): 1.53e-46: 189: 10.71
+	Hs
		717011 CTNB1_HUMAN (234-851): 2.18e-137: 429: 14.99		DYST_HUMAN (19-1901): 3.23e-25: 118: 9.49
+	Hs
		626291 APC_HUMAN (24-771): 1.07e-107: 368: 14.78		MACF1_HUMAN (883-3859): 6.57e-41: 170: 8.89
+	Hs
		148191 CTND1_HUMAN (37-881): 7.13e-149: 465: 20.87		CTRO_HUMAN (18-648): 1.78e-09: 66.5: 12.83
+	Hs
		551814 PKP4_HUMAN (27-880): 1.06e-141: 452: 22.22		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94
+	Rn
		100236 CTNB1_RAT (234-851): 1.25e-136: 428: 14.99		F7F9U6_RAT (147-981): 1.18e-16: 90.4: 13.80
+	Hs
		716818 CTNB1_HUMAN (234-851): 2.18e-137: 429: 14.99		MYH9_HUMAN (135-781): 3.02e-14: 82.3: 15.29
+	Hs
		148453 CTNB1_HUMAN (234-851): 2.18e-137: 429: 14.99		CTRO_HUMAN (18-648): 1.78e-09: 66.5: 12.83
+	Hs
		717387 CTNB1_HUMAN (234-851): 2.18e-137: 429: 14.99		DAPLE_HUMAN (2137-2753): 8.15e-09: 64.2: 14.04
+	Hs
		149461 PKP3_HUMAN (29-870): 8.19e-134: 421: 23.03		CTRO_HUMAN (18-648): 1.78e-09: 66.5: 12.83
+	Hs
		551876 PKP3_HUMAN (29-870): 8.19e-134: 421: 23.03		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94
+	Hs
		542219 PLAK_HUMAN (224-861): 1.84e-128: 405: 15.22		MYH9_HUMAN (135-781): 3.02e-14: 82.3: 15.29
+	Hs
		626103 APC_HUMAN (24-771): 1.07e-107: 368: 14.78		DYST_HUMAN (19-1901): 3.23e-25: 118: 9.49
+	Hs
		148354 PLAK_HUMAN (224-861): 1.84e-128: 405: 15.22		CTRO_HUMAN (18-648): 1.78e-09: 66.5: 12.83
+	Hs
		542168 PLAK_HUMAN (224-861): 1.84e-128: 405: 15.22		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94
+	Hs
		551698 PKP1_HUMAN (107-879): 1.85e-125: 397: 22.99		DESP_HUMAN (2135-3311): 1.98e-09: 66.5: 13.94