HitPredict

Interactor 1: MYOC (Q99972)
Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
Gene: MYOC

Interactor 2: MYOC (Q99972)
Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
Gene: MYOC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.793

The method score is based on:

Property Details
Experiments 16289162, 11773029
Identification Methods two hybrid, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains OLF~OLF
Common GO terms GO:0001649 - osteoblast differentiation
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding
GO:0005109 - frizzled binding
GO:0005615 - extracellular space
and 32 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 504
Hs

1 504
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Xl

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024