HitPredict

Interactor 1: GDF15 (Q99988)
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
Gene: GDF15

Interactor 2: GDF15 (Q99988)
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
Gene: GDF15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 10811612, 9326641, 28953886
Identification Methods affinity chromatography technology, x-ray crystallography
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains TGF_beta~TGF_beta
Common GO terms GO:0002023 - reduction of food intake in response to dietary excess
GO:0002686 - negative regulation of leukocyte migration
GO:0005125 - cytokine activity
GO:0005179 - hormone activity
GO:0005576 - extracellular region
and 22 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024