HitPredict

Interactor 1: FOXP3 (Q99JB6)
Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]
Gene: FOXP3

Interactor 2: FOXP4 (Q9DBY0)
Forkhead box protein P4 (Fork head-related protein-like A) (mFKHLA)
Gene: FOXP4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22922362
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Forkhead~Forkhead
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 429 Mm			1 795
+	Hs
		1217560 FOXP3_HUMAN (1-429): 0: 613: 86.51		FOXP4_HUMAN (1-672): 1.73e-140: 432: 89.65
+	Mm
		885729 FOXP3_MOUSE (1-429): 0: 634: 100.00		FOXP1_MOUSE (1-671): 7.04e-127: 397: 51.69
+	Hs
		1318364 FOXP3_HUMAN (1-429): 0: 613: 86.51		FOXP1_HUMAN (1-671): 5.29e-127: 396: 52.46
+	Hs
		178992 FOXP3_HUMAN (1-429): 0: 613: 86.51		FOXP2_HUMAN (207-671): 2.8e-92: 306: 57.74
+	Mm
		1307663 FOXP3_MOUSE (1-429): 0: 634: 100.00		FOXP3_MOUSE (236-551): 2.69e-64: 223: 38.77
+	Hs
		1318361 FOXP3_HUMAN (1-429): 0: 613: 86.51		FOXP3_HUMAN (236-551): 1.65e-61: 215: 38.46
+	Mm
		1307749 FOXP3_MOUSE (1-429): 0: 634: 100.00		FOXO3_MOUSE (322-785): 2.61e-51: 192: 16.38
+	Mm
		1307743 FOXP3_MOUSE (1-429): 0: 634: 100.00		FOXO1_MOUSE (448-772): 9.76e-50: 187: 20.34
+	Hs
		878007 FOXP3_HUMAN (1-429): 0: 613: 86.51		FOXA3_HUMAN (378-584): 1.4e-40: 154: 23.87
+	Hs
		1217562 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXP4_HUMAN (1-672): 1.73e-140: 432: 89.65
+	Hs
		1329965 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXP1_HUMAN (1-671): 5.29e-127: 396: 52.46
+	Hs
		178993 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXP2_HUMAN (207-671): 2.8e-92: 306: 57.74
+	Hs
		178935 FOXP2_HUMAN (172-426): 8.75e-99: 312: 44.16		FOXP2_HUMAN (207-671): 2.8e-92: 306: 57.74
+	Dm
		1367006 Q9VH87_DROME (190-421): 4.58e-107: 325: 39.15		Q9VH87_DROME (306-562): 2.84e-74: 250: 49.28
+	Hs
		1021066 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXF1_HUMAN (413-727): 1.81e-44: 166: 17.51
+	Hs
		1021253 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXI1_HUMAN (399-620): 1.27e-38: 149: 23.73
+	Hs
		1021347 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXL1_HUMAN (413-649): 4.75e-39: 149: 25.69
+	Hs
		1021162 FOXP1_HUMAN (172-426): 1.51e-99: 313: 44.32		FOXC1_HUMAN (458-535): 9.23e-12: 70.5: 43.37
+	Hs
		178963 FOXP2_HUMAN (172-426): 8.75e-99: 312: 44.16		FOXC1_HUMAN (458-535): 9.23e-12: 70.5: 43.37