HitPredict

Interactor 1: Q99JJ1 (Q99JJ1)
Cry2 protein
Gene: Cry2

Interactor 2: BMAL1 (Q9WTL8)
Basic helix-loop-helix ARNT-like protein 1 (Arnt3) (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Brain and muscle ARNT-like 1)
Gene: BMAL1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	18430226
Identification Methods	gal4 vp16 complementation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032922 - circadian regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 243 Mm			1 632
+	Mm
		1351674 CRY2_MOUSE (1-243): 1.59e-140: 408: 100.00		BMAL1_MOUSE (1-632): 0: 669: 100.00
+	Hs
		126133 CRY2_HUMAN (1-243): 1.92e-131: 384: 93.83		BMAL1_HUMAN (1-632): 0: 645: 97.16
+	Mm
		956913 CRY1_MOUSE (1-174): 7.28e-98: 299: 86.21		BMAL1_MOUSE (1-632): 0: 669: 100.00
+	Hs
		126131 CRY1_HUMAN (1-174): 1.74e-98: 300: 86.21		BMAL1_HUMAN (1-632): 0: 645: 97.16
+	Hs
		1082134 CRY1_HUMAN (1-174): 1.74e-98: 300: 86.21		BMAL2_HUMAN (8-632): 0: 531: 48.44
+	Mm
		956899 CRY1_MOUSE (1-174): 7.28e-98: 299: 86.21		BMAL2_MOUSE (33-632): 2.38e-163: 481: 44.76
+	Mm
		139878 CRY2_MOUSE (1-243): 1.59e-140: 408: 100.00		CLOCK_MOUSE (56-589): 6.56e-105: 338: 24.30
+	Mm
		139874 Q99JJ1_MOUSE (1-243): 2.61e-144: 404: 100.00		CLOCK_MOUSE (56-589): 6.56e-105: 338: 24.30
+	Mm
		222714 CRY2_MOUSE (1-243): 1.59e-140: 408: 100.00		PER2_MOUSE (9-600): 5.46e-97: 325: 17.77
+	Hs
		181527 CRY2_HUMAN (1-243): 1.92e-131: 384: 93.83		CLOCK_HUMAN (56-589): 2.32e-103: 334: 24.49
+	Hs
		165988 CRY2_HUMAN (1-243): 1.92e-131: 384: 93.83		PER2_HUMAN (8-600): 5.92e-97: 325: 17.36
+	Hs
		1115749 CRY2_HUMAN (1-243): 1.92e-131: 384: 93.83		NPAS2_HUMAN (71-613): 1.27e-96: 316: 23.51
+	Mm
		139864 CRY1_MOUSE (1-174): 7.28e-98: 299: 86.21		CLOCK_MOUSE (56-589): 6.56e-105: 338: 24.30
+	Hs
		181525 CRY1_HUMAN (1-174): 1.74e-98: 300: 86.21		CLOCK_HUMAN (56-589): 2.32e-103: 334: 24.49
+	Hs
		165986 CRY1_HUMAN (1-174): 1.74e-98: 300: 86.21		PER2_HUMAN (8-600): 5.92e-97: 325: 17.36
+	Mm
		222694 CRY1_MOUSE (1-174): 7.28e-98: 299: 86.21		PER2_MOUSE (9-600): 5.46e-97: 325: 17.77
+	Hs
		1082145 CRY1_HUMAN (1-174): 1.74e-98: 300: 86.21		NPAS2_HUMAN (71-613): 1.27e-96: 316: 23.51