HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19451267
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_1~LRR_1, LRR_1~LRR_8, LRR_8~LRR_8, TIR~TIR, Tlr3_TMD~Tlr3_TMD
Common GO terms	GO:0000165 - MAPK cascade GO:0001774 - microglial cell activation GO:0002224 - toll-like receptor signaling pathway GO:0002730 - regulation of dendritic cell cytokine production GO:0003725 - double-stranded RNA binding and 46 others more... GO:0004888 - transmembrane signaling receptor activity GO:0005769 - early endosome GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0006952 - defense response GO:0006954 - inflammatory response GO:0007254 - JNK cascade GO:0008584 - male gonad development GO:0009615 - response to virus GO:0009986 - cell surface GO:0010008 - endosome membrane GO:0032481 - positive regulation of type I interferon production GO:0032722 - positive regulation of chemokine production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0032729 - positive regulation of type II interferon production GO:0032735 - positive regulation of interleukin-12 production GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0034138 - toll-like receptor 3 signaling pathway GO:0034343 - type III interferon production GO:0034346 - positive regulation of type III interferon production GO:0035458 - cellular response to interferon-beta GO:0038023 - signaling receptor activity GO:0038187 - pattern recognition receptor activity GO:0043065 - positive regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043330 - response to exogenous dsRNA GO:0043331 - response to dsRNA GO:0045087 - innate immune response GO:0045766 - positive regulation of angiogenesis GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046330 - positive regulation of JNK cascade GO:0051607 - defense response to virus GO:0060907 - positive regulation of macrophage cytokine production GO:0071260 - cellular response to mechanical stimulus GO:0071346 - cellular response to type II interferon GO:0071360 - cellular response to exogenous dsRNA GO:0071466 - cellular response to xenobiotic stimulus GO:0090594 - inflammatory response to wounding GO:0097191 - extrinsic apoptotic signaling pathway GO:0097527 - necroptotic signaling pathway GO:0098586 - cellular response to virus GO:1900017 - positive regulation of cytokine production involved in inflammatory response GO:1901224 - positive regulation of non-canonical NF-kappaB signal transduction
Homologous interactions	19