HitPredict

Interactor 1: MACD1 (Q9BQ69)
ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
Gene: MACROD1

Interactor 2: PARP2 (Q9UGN5)
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)
Gene: PARP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 583
+	Hs
		455808 MACD1_HUMAN (1-325): 4.04e-162: 456: 100.00		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		1349691 H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		260727 H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455952 H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455634 PARP9_HUMAN (80-320): 1.65e-41: 155: 20.33		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		260693 H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11		TNKS1_HUMAN (294-577): 4.32e-59: 215: 20.24