HitPredict

Interactor 1: TBL1Y (Q9BQ87)
F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked)
Gene: TBL1Y

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 522 Hs			1 2514
+	Hs
		1346974 NLE1_HUMAN (13-344): 4.23e-58: 202: 12.17		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1164188 BRWD3_HUMAN (267-522): 1.73e-50: 188: 17.63		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		245652 TBL1X_HUMAN (12-307): 3.79e-39: 151: 15.99		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		261578 TBL1Y_HUMAN (1-522): 1.82e-157: 460: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Xl
		1093463 TB1RA_XENLA (12-307): 6.18e-40: 153: 15.70		Q1W3Z6_XENLA (4-2514): 7.45e-150: 523: 51.60
+	Hs
		261584 TBL1R_HUMAN (12-307): 6.61e-40: 153: 15.70		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		245548 TBL1X_HUMAN (12-307): 3.79e-39: 151: 15.99		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261563 SNR40_HUMAN (1-302): 3.14e-39: 148: 15.96		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Xl
		1186358 TB1RA_XENLA (12-307): 6.18e-40: 153: 15.70		NCOR1_XENLA (1-2514): 7.28e-122: 434: 32.87
+	Hs
		1281467 FBXW7_HUMAN (1-433): 1.43e-68: 235: 16.07		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		1346970 NLE1_HUMAN (13-344): 4.23e-58: 202: 12.17		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		793042 LIS1_HUMAN (314-522): 1.08e-57: 198: 25.11		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		245648 TBL1X_HUMAN (12-307): 3.79e-39: 151: 15.99		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Mm
		1206586 TBL1R_MOUSE (12-307): 6.81e-40: 153: 15.70		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Mm
		1206786 TBL1X_MOUSE (12-307): 6.43e-39: 150: 15.70		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Hs
		1281391 FBXW7_HUMAN (1-433): 1.43e-68: 235: 16.07		PRR36_HUMAN (2-1025): 1.03e-10: 69.6: 8.95
+	Hs
		1302927 NLE1_HUMAN (13-344): 4.23e-58: 202: 12.17		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		297832 BRWD3_HUMAN (267-522): 1.73e-50: 188: 17.63		K0754_HUMAN (1962-2483): 2.12e-10: 69.1: 14.34
+	Hs
		903450 WDR5_HUMAN (13-303): 4.12e-41: 152: 12.93		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		903374 WDR5_HUMAN (13-303): 4.12e-41: 152: 12.93		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93