HitPredict

Interactor 1: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	30282801, 28886238, 32711345
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 342 Hs			1 400
+	Hs
		1344499 NLE1_HUMAN (114-333): 2.06e-53: 184: 18.05		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		725575 COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1281302 FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1236482 TBL1R_HUMAN (206-337): 3.38e-19: 90.1: 13.01		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87