HitPredict

Interactor 1: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Interactor 2: LSM4 (Q9Y4Z0)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)
Gene: LSM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28977470, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 342 Hs			1 139
+	Hs
		912368 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Hs
		912716 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		1281669 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		LSM10_HUMAN (3-104): 9.38e-28: 100: 24.51
+	Hs
		911945 MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Hs
		912348 FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Hs
		912695 FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		903646 WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79		LSM4_HUMAN (1-139): 4.8e-47: 150: 100.00
+	Hs
		197113 PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40		LSM4_HUMAN (1-139): 4.8e-47: 150: 100.00
+	Hs
		903627 WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		903091 WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Sc
		767803 COPA_YEAST (131-323): 1.27e-23: 104: 16.81		LSM4_YEAST (1-98): 9.17e-25: 95.1: 36.11
+	Hs
		903093 WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		903090 WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Hs
		197110 PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		196993 PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		196988 PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82