HitPredict

Interactor 1: COR1B (Q9BR76)
Coronin-1B (Coronin-2)
Gene: CORO1B

Interactor 2: COR1C (Q9ULV4)
Coronin-1C (Coronin-3) (hCRNN4)
Gene: CORO1C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	35271311, 28514442, 33961781, 26655834
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DUF1899~WD40, DUF1899~WD40_4, WD40~WD40, WD40~WD40_4
Common GO terms	GO:0005925 - focal adhesion GO:0007015 - actin filament organization GO:0030027 - lamellipodium GO:0051015 - actin filament binding GO:2000394 - positive regulation of lamellipodium morphogenesis
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 489 Hs			1 474
+	Hs
		1163301 COR1B_HUMAN (1-489): 1.7e-130: 388: 100.00		CORO6_HUMAN (2-472): 9.42e-130: 385: 69.00
+	Hs
		1163316 COR1C_HUMAN (4-484): 1.14e-119: 360: 72.77		CORO6_HUMAN (2-472): 9.42e-130: 385: 69.00
+	Hs
		678302 COR1B_HUMAN (1-489): 1.7e-130: 388: 100.00		COR1A_HUMAN (2-467): 2.74e-113: 343: 64.24
+	Mm
		292620 COR1B_MOUSE (1-488): 2.29e-128: 383: 94.26		COR1A_MOUSE (2-467): 1.86e-112: 341: 64.24
+	Hs
		678279 COR1A_HUMAN (4-481): 3.61e-109: 333: 63.47		CORO6_HUMAN (2-472): 9.42e-130: 385: 69.00
+	Hs
		678320 COR1C_HUMAN (4-484): 1.14e-119: 360: 72.77		COR1A_HUMAN (2-467): 2.74e-113: 343: 64.24
+	Mm
		292621 COR1C_MOUSE (4-484): 1.01e-119: 360: 73.39		COR1A_MOUSE (2-467): 1.86e-112: 341: 64.24
+	Mm
		292586 COR1A_MOUSE (4-481): 3.96e-108: 330: 63.05		COR1A_MOUSE (2-467): 1.86e-112: 341: 64.24
+	Hs
		678293 COR1A_HUMAN (4-481): 3.61e-109: 333: 63.47		POC1B_HUMAN (2-211): 1.38e-49: 177: 18.57
+	Hs
		678297 COR1A_HUMAN (4-481): 3.61e-109: 333: 63.47		COR2A_HUMAN (4-212): 5.87e-25: 109: 10.46
+	Hs
		1271431 COR2A_HUMAN (1-487): 6.49e-96: 301: 44.13		COR2B_HUMAN (4-218): 5.03e-25: 109: 10.13
+	Hs
		678289 COR1A_HUMAN (4-481): 3.61e-109: 333: 63.47		POC1A_HUMAN (260-415): 6.64e-14: 75.3: 10.69
+	Hs
		1240442 POC1B_HUMAN (4-253): 3.75e-59: 204: 17.60		POC1A_HUMAN (260-415): 6.64e-14: 75.3: 10.69