HitPredict

Interactor 1: PSDE (O00487)
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)
Gene: PSMD14

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	17353931, 28539385, 35530310, 17323924
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 310 Hs			1 392
+	Ce
		954231 CSN5_CAEEL (1-292): 1.38e-72: 230: 26.47		LIS1_CAEEL (1-248): 8.65e-67: 218: 18.02
+	Sc
		797501 RPN11_YEAST (1-310): 1.59e-93: 281: 64.84		COPA_YEAST (3-376): 1.92e-44: 166: 10.58
+	Hs
		921026 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		GBB1_HUMAN (6-283): 1.85e-46: 164: 19.66
+	Hs
		130829 PSDE_HUMAN (1-310): 1.28e-110: 324: 100.00		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Sc
		797491 RPN11_YEAST (1-310): 1.59e-93: 281: 64.84		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		849262 PSMD7_HUMAN (28-185): 3.22e-34: 128: 22.56		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		903414 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		1272699 CSN5_HUMAN (1-305): 6.24e-83: 255: 28.35		PRP19_HUMAN (89-204): 4.23e-13: 72.4: 33.06
+	Sc
		860042 RPN8_YEAST (29-185): 1.1e-11: 66.7: 26.38		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49