HitPredict

Interactor 1: ESYT1 (Q9BSJ8)
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Gene: ESYT1

Interactor 2: TMX1 (Q9H3N1)
Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Gene: TMX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	27173435, 37931956, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1104 Hs			1 280
+	Hs
		1310891 ESYT1_HUMAN (1-1104): 0: 874: 100.00		ERP44_HUMAN (1-161): 1.35e-38: 141: 23.12
+	Hs
		1055313 ESYT1_HUMAN (1-1104): 0: 874: 100.00		PDIA5_HUMAN (5-228): 1.07e-33: 129: 14.58
+	Hs
		48503 ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32		TMX1_HUMAN (1-280): 1.13e-79: 243: 100.00
+	Dm
		1179583 Q7K3H0_DROME (922-1095): 2.72e-14: 80.1: 33.52		PDIA6_DROME (6-275): 8.21e-60: 197: 17.51
+	Hs
		48482 ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32		ERP44_HUMAN (1-161): 1.35e-38: 141: 23.12