HitPredict

Interactor 1: NFIP1 (Q9BT67)
NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)
Gene: NDFIP1

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.50	0.599

Property	Details
Experiments	35264565, 29635000, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 922
+	Hs
		1294848 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Mm
		1208047 NFIP1_MOUSE (1-221): 1.54e-136: 383: 97.29		ITCH_MOUSE (1-922): 0: 862: 57.54
+	Hs
		1327920 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		125686 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		1299617 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		1294871 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125746 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		1299647 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808249 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Mm
		93279 NFIP1_MOUSE (1-221): 1.54e-136: 383: 97.29		E9PXB7_MOUSE (129-919): 0: 696: 34.71
+	Hs
		808291 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Dm
		1374794 Q9VVJ5_DROME (100-221): 4.9e-53: 173: 40.98		SUDX_DROME (14-922): 0: 832: 52.00
+	Dm
		1374786 Q9VVJ5_DROME (100-221): 4.9e-53: 173: 40.98		NEDD4_DROME (3-920): 0: 759: 30.21
+	Mm
		808368 NFIP1_MOUSE (1-221): 1.54e-136: 383: 97.29		NEDD4_MOUSE (3-446): 4.73e-51: 195: 18.83
+	Rn
		1137274 NFIP1_RAT (1-221): 2.44e-135: 380: 97.74		NEDD4_RAT (10-425): 7.95e-51: 195: 19.38
+	Hs
		1311860 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Dm
		1360300 Q9VVJ5_DROME (100-221): 4.9e-53: 173: 40.98		SMUF1_DROME (16-538): 1.82e-25: 115: 13.02