Interactor 1: DERL1 (Q9BUN8)
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Gene: DERL1

Interactor 2: DERL2 (Q9GZP9)
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
Gene: DERL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 22119785, 16186509, 23867461
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DER1~DER1
Common GO terms GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005047 - signal recognition particle binding
GO:0005769 - early endosome
GO:0005770 - late endosome
GO:0005783 - endoplasmic reticulum
and 8 others

more...

Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 251
Hs

1 239
+ Hs
+ Ce
+ Ce
+ Ce
+ At
+ At
+ At
+ Sc
+ Sc
+ Sc
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024