HitPredict

Interactor 1: DDX23 (Q9BUQ8)
Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
Gene: DDX23

Interactor 2: LSM7 (Q9UK45)
U6 snRNA-associated Sm-like protein LSm7
Gene: LSM7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 820 Hs			1 103
+	Hs
		928011 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		RSMN_HUMAN (8-96): 2.99e-25: 96.1: 28.57
+	Hs
		539132 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		RSMB_HUMAN (8-96): 5.05e-25: 95.7: 28.57
+	Hs
		912103 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		RUXG_HUMAN (8-90): 4.16e-24: 88.8: 32.53
+	Hs
		167714 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		LSM1_HUMAN (14-101): 1.32e-21: 84.2: 29.55
+	Hs
		68454 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		RUXGL_HUMAN (8-90): 2.38e-22: 84.2: 31.33
+	Hs
		539083 DDX17_HUMAN (337-820): 5.87e-132: 412: 34.97		RSMB_HUMAN (8-96): 5.05e-25: 95.7: 28.57
+	Hs
		538830 DDX5_HUMAN (297-801): 3.08e-129: 401: 32.81		RSMB_HUMAN (8-96): 5.05e-25: 95.7: 28.57
+	Sc
		416016 DED1_YEAST (348-797): 3.22e-126: 393: 33.55		LSM1_YEAST (15-95): 4.3e-22: 86.5: 25.93
+	Sc
		415993 DED1_YEAST (348-797): 3.22e-126: 393: 33.55		RUXG_YEAST (11-90): 1.08e-21: 82.7: 35.80
+	Hs
		539176 DDX41_HUMAN (365-795): 7.12e-81: 273: 39.32		RSMB_HUMAN (8-96): 5.05e-25: 95.7: 28.57