HitPredict

Interactor 1: DDX23 (Q9BUQ8)
Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
Gene: DDX23

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 820 Hs			1 95
+	Hs
		1313233 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		912370 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		912721 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		911952 DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Sc
		624214 DBP1_YEAST (240-798): 6.65e-132: 408: 29.38		LSM2_YEAST (1-95): 2.94e-31: 106: 63.16
+	Dm
		1367408 DDX3_DROME (171-802): 1.4e-128: 405: 26.82		SMD1_DROME (1-94): 3.73e-29: 102: 30.85
+	Hs
		133961 DDX3X_HUMAN (236-804): 2.78e-130: 405: 30.65		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Hs
		571387 DDX5_HUMAN (297-801): 3.08e-129: 401: 32.81		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Sc
		415988 DED1_YEAST (348-797): 3.22e-126: 393: 33.55		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83
+	Dm
		580755 DDX17_DROME (373-773): 2.28e-80: 275: 40.79		SMD1_DROME (1-94): 3.73e-29: 102: 30.85
+	Hs
		912397 DDX41_HUMAN (365-795): 7.12e-81: 273: 39.32		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		912751 DDX41_HUMAN (365-795): 7.12e-81: 273: 39.32		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69