HitPredict

Interactor 1: FICD (Q9BVA6)
Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin yeast partner E) (Huntingtin-interacting protein 13) (HIP-13) (Huntingtin-interacting protein E)
Gene: FICD

Interactor 2: FICD (Q9BVA6)
Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin yeast partner E) (Huntingtin-interacting protein 13) (HIP-13) (Huntingtin-interacting protein E)
Gene: FICD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

The method score is based on:

Property	Details
Experiments	22266942, 25435325
Identification Methods	ampylation assay, molecular sieving, x ray scattering, x-ray crystallography
Interaction Type	ampylation reaction, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	Fic~Fic
Common GO terms	GO:0005524 - ATP binding GO:0005789 - endoplasmic reticulum membrane GO:0006986 - response to unfolded protein GO:0018117 - protein adenylylation GO:0030544 - Hsp70 protein binding and 8 others more... GO:0034260 - negative regulation of GTPase activity GO:0034976 - response to endoplasmic reticulum stress GO:0042803 - protein homodimerization activity GO:0044602 - protein deadenylylation GO:0044603 - protein adenylylhydrolase activity GO:0051087 - protein-folding chaperone binding GO:0070733 - AMPylase activity GO:1903894 - regulation of IRE1-mediated unfolded protein response
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	458
Hs

1	458

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024