HitPredict

Interactor 1: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Interactor 2: MED13 (Q9UHV7)
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
Gene: MED13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	24981860, 26186194, 28514442, 33961781, 32707033, 23602568, 23746844
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990508 - CKM complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 2174
+	Mm
		1131974 CDK8_MOUSE (1-502): 7.79e-153: 445: 76.49		MED13_MOUSE (1-2174): 0: 3486: 93.61
+	Hs
		826370 CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69		MED13_HUMAN (1-2174): 0: 3460: 100.00
+	Hs
		73048 B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00		MED13_HUMAN (1-2174): 0: 3460: 100.00
+	Hs
		1174776 CDK19_HUMAN (1-502): 1.67e-157: 459: 100.00		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Hs
		826302 CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Hs
		73031 B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Dm
		1182305 CDK8_DROME (1-413): 7.19e-138: 407: 77.24		MED13_DROME (776-947): 6.01e-50: 198: 25.11