HitPredict

Interactor 1: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Interactor 2: MED16 (Q9Y2X0)
Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)
Gene: MED16

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	24981860, 26186194, 28514442, 33961781, 32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 877
+	Hs
		826379 CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69		MED16_HUMAN (1-877): 0: 1537: 100.00
+	Hs
		73050 B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00		MED16_HUMAN (1-877): 0: 1537: 100.00
+	Dm
		1373828 CDK8_DROME (1-413): 7.19e-138: 407: 77.24		MED16_DROME (13-824): 0: 1049: 28.80