HitPredict

Interactor 1: CAR14 (Q9BXL6)
Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2)
Gene: CARD14

Interactor 2: MALT1 (Q9UDY8)
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)
Gene: MALT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27113748, 27071417
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007250 - activation of NF-kappaB-inducing kinase activity GO:0043066 - negative regulation of apoptotic process GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1004 Hs			1 824
+	Hs
		1329066 CARD9_HUMAN (15-460): 1.54e-155: 472: 30.87		MALT1_HUMAN (1-824): 0: 879: 100.00
+	Hs
		1315464 CAR11_HUMAN (13-1001): 5.09e-90: 314: 25.64		MALT1_HUMAN (1-824): 0: 879: 100.00
+	Mm
		885967 CAR10_MOUSE (12-316): 3.5e-10: 66.2: 11.71		MALT1_MOUSE (1-823): 0: 876: 86.42
+	Hs
		159144 CSKP_HUMAN (411-1002): 3.77e-73: 262: 10.65		FGFR1_HUMAN (1-585): 6.42e-87: 295: 13.37
+	Hs
		508118 DLG5_HUMAN (430-662): 1.81e-14: 80.4: 18.03		FGFR1_HUMAN (1-585): 6.42e-87: 295: 13.37
+	Hs
		601553 DLG5_HUMAN (430-662): 1.81e-14: 80.4: 18.03		FGFR2_HUMAN (10-585): 9.76e-85: 289: 14.03
+	Dm
		1308476 Q9W3H8_DROME (563-1001): 3.08e-77: 278: 13.87		Q9BN17_DROME (119-297): 4.03e-12: 72.4: 16.84
+	Hs
		608056 DLG5_HUMAN (430-662): 1.81e-14: 80.4: 18.03		FGFR4_HUMAN (109-423): 1.11e-43: 172: 14.82