HitPredict

Interactor 1: STK25 (O00506)
Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)
Gene: STK25

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	20098747
Identification Methods	pull down, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0042803 - protein homodimerization activity GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 426 Hs			1 419
+	Mm
		291781 AKT1_MOUSE (6-330): 1.11e-131: 389: 25.75		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		682095 AKT1_HUMAN (6-330): 4.86e-131: 387: 25.75		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		551881 STK24_HUMAN (8-424): 7.71e-143: 416: 71.12		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		682219 AKT2_HUMAN (9-330): 5.71e-132: 389: 24.55		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		551616 AKT1_HUMAN (6-330): 4.86e-131: 387: 25.75		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		681696 AKT1_HUMAN (6-330): 4.86e-131: 387: 25.75		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		568567 KAPCA_HUMAN (4-322): 7.9e-132: 384: 22.32		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		568568 KAPCA_HUMAN (4-322): 7.9e-132: 384: 22.32		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		522538 KAPCB_HUMAN (4-315): 1.97e-131: 383: 23.75		MYH1_HUMAN (33-391): 2.48e-10: 65: 11.75
+	Hs
		528359 KAPCB_HUMAN (4-315): 1.97e-131: 383: 23.75		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		522546 STK3_HUMAN (2-295): 3.42e-128: 380: 51.01		MYH1_HUMAN (33-391): 2.48e-10: 65: 11.75
+	Hs
		522545 STK4_HUMAN (3-284): 1.11e-127: 379: 52.80		MYH1_HUMAN (33-391): 2.48e-10: 65: 11.75
+	Hs
		610795 KAPCB_HUMAN (4-315): 1.97e-131: 383: 23.75		MYH2_HUMAN (1-396): 8.43e-09: 60: 9.77
+	Hs
		610802 KAPCB_HUMAN (4-315): 1.97e-131: 383: 23.75		MYH4_HUMAN (21-393): 8.88e-09: 60: 13.44
+	Hs
		522610 STK3_HUMAN (2-295): 3.42e-128: 380: 51.01		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528371 STK3_HUMAN (2-295): 3.42e-128: 380: 51.01		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		528409 STK3_HUMAN (2-295): 3.42e-128: 380: 51.01		MYH8_HUMAN (22-392): 1.71e-09: 62.3: 11.87
+	Hs
		522609 STK4_HUMAN (3-284): 1.11e-127: 379: 52.80		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528369 STK4_HUMAN (3-284): 1.11e-127: 379: 52.80		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		1027452 STK3_HUMAN (2-295): 3.42e-128: 380: 51.01		MYH2_HUMAN (1-396): 8.43e-09: 60: 9.77