HitPredict

Interactor 1: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Interactor 2: DLGP2 (Q9P1A6)
Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)
Gene: DLGAP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.791

Property	Details
Experiments	10527873, 21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1731 Hs			1 1054
+	Mm
		1116003 SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71		DLGP2_MOUSE (1-1054): 0: 1497: 89.14
+	Hs
		1349917 SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04		DLGP2_HUMAN (1-1054): 0: 1549: 100.00
+	Hs
		145954 SHAN3_HUMAN (1-1731): 0: 596: 100.00		DLGP1_HUMAN (80-1054): 0: 1202: 52.16
+	Mm
		1116115 SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71		DLGP1_MOUSE (80-1054): 0: 1180: 51.11
+	Rn
		956996 SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31		DLGP1_RAT (80-1054): 0: 1184: 51.11
+	Hs
		327247 SHAN3_HUMAN (1-1731): 0: 596: 100.00		DLGP3_HUMAN (80-1054): 0: 1074: 45.72
+	Hs
		145956 SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04		DLGP1_HUMAN (80-1054): 0: 1202: 52.16
+	Mm
		1115961 SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71		DLGP3_MOUSE (80-1054): 0: 1042: 45.39
+	Rn
		102520 SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31		G3V7T8_RAT (80-1054): 0: 1050: 45.29
+	Rn
		957003 SHAN1_RAT (366-1726): 2.72e-29: 130: 14.04		DLGP2_RAT (1-1054): 0: 1482: 89.14
+	Hs
		1316315 SHAN3_HUMAN (1-1731): 0: 596: 100.00		DLGP4_HUMAN (80-1054): 0: 955: 42.72
+	Rn
		956997 SHAN2_RAT (356-1728): 1.67e-96: 346: 35.84		DLGP1_RAT (80-1054): 0: 1184: 51.11
+	Mm
		1194593 SHAN2_MOUSE (356-1728): 4.66e-97: 348: 35.75		DLGP1_MOUSE (80-1054): 0: 1180: 51.11
+	Mm
		69915 SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71		DLGP4_MOUSE (80-1054): 0: 931: 41.99
+	Hs
		327248 SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04		DLGP3_HUMAN (80-1054): 0: 1074: 45.72
+	Hs
		1357785 SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04		DLGP4_HUMAN (80-1054): 0: 955: 42.72
+	Rn
		956998 SHAN1_RAT (366-1726): 2.72e-29: 130: 14.04		DLGP1_RAT (80-1054): 0: 1184: 51.11
+	Hs
		145958 SHAN1_HUMAN (320-1726): 3.34e-22: 107: 13.60		DLGP1_HUMAN (80-1054): 0: 1202: 52.16
+	Mm
		88376 SHAN1_MOUSE (323-1726): 7.25e-25: 115: 13.87		DLGP1_MOUSE (80-1054): 0: 1180: 51.11