HitPredict

Interactor 1: YTHD1 (Q9BYJ9)
YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1)
Gene: YTHDF1

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30209976, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0010494 - cytoplasmic stress granule
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 559 Hs			1 1191
+	Hs
		1335263 YTHD2_HUMAN (1-558): 1.49e-138: 415: 62.72		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1192380 YTHD3_HUMAN (1-541): 4.01e-131: 396: 65.91		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1332440 YTDC2_HUMAN (226-535): 2.61e-51: 192: 23.18		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1298137 YTDC1_HUMAN (301-554): 6.03e-45: 171: 22.22		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1136271 YTHD1_HUMAN (1-559): 2.02e-141: 422: 100.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136382 YTHD2_HUMAN (1-558): 1.49e-138: 415: 62.72		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136147 YTHD3_HUMAN (1-541): 4.01e-131: 396: 65.91		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136291 YTDC2_HUMAN (226-535): 2.61e-51: 192: 23.18		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136237 YTDC1_HUMAN (301-554): 6.03e-45: 171: 22.22		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		257693 YTHD1_HUMAN (1-559): 2.02e-141: 422: 100.00		ANR17_HUMAN (335-957): 1.44e-12: 74.7: 8.44
+	Hs
		257727 YTHD2_HUMAN (1-558): 1.49e-138: 415: 62.72		ANR17_HUMAN (335-957): 1.44e-12: 74.7: 8.44
+	Hs
		1270848 YTHD2_HUMAN (1-558): 1.49e-138: 415: 62.72		CBP_HUMAN (556-893): 1.74e-09: 64.6: 9.77
+	Hs
		257641 YTHD3_HUMAN (1-541): 4.01e-131: 396: 65.91		ANR17_HUMAN (335-957): 1.44e-12: 74.7: 8.44
+	Mm
		1351630 PCLO_MOUSE (139-370): 1.14e-09: 63.8: 14.52		PCLO_MOUSE (522-1015): 6.21e-15: 82.8: 8.09
+	Dm
		113976 M9PB30_DROME (54-344): 7.98e-11: 67.6: 14.53		M9PB30_DROME (683-1171): 5.39e-11: 69.7: 12.25