HitPredict

Interactor 1: WNK3 (Q9BYP7)
Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)
Gene: WNK3

Interactor 2: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 32707033, 35271311, 34349018
Identification Methods affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains OSR1_C~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 14 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1800
Hs

1 2382
+ Hs
+ Os
+ Rn
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Mm
+ At
+ Hs
+ Hs
+ Hs
+ At
+ At
+ Hs

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Last updated: 15 Jul 2024