HitPredict

Interactor 1: WNK3 (Q9BYP7)
Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)
Gene: WNK3

Interactor 2: KLHL3 (Q9UH77)
Kelch-like protein 3
Gene: KLHL3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	35179207, 23387299, 23838290, 24641320
Identification Methods	x-ray crystallography, pull down, affinity chromatography technology, unspecified method
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0050801 - monoatomic ion homeostasis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1800 Hs			1 587
+	Hs
		307211 WNK3_HUMAN (1-1800): 0: 1277: 100.00		KLHL2_HUMAN (1-587): 7.51e-180: 522: 76.53
+	Hs
		682058 AKT1_HUMAN (37-470): 5.05e-133: 425: 17.48		KLHL3_HUMAN (1-587): 0: 547: 100.00
+	Hs
		1355222 WNK2_HUMAN (1-719): 2.5e-112: 400: 49.73		KLHL3_HUMAN (1-587): 0: 547: 100.00
+	Hs
		307234 WNK2_HUMAN (1-719): 2.5e-112: 400: 49.73		KLHL2_HUMAN (1-587): 7.51e-180: 522: 76.53
+	Hs
		1330745 WNK1_HUMAN (27-1637): 1.09e-101: 366: 26.62		KLHL3_HUMAN (1-587): 0: 547: 100.00
+	Hs
		307216 WNK1_HUMAN (27-1637): 1.09e-101: 366: 26.62		KLHL2_HUMAN (1-587): 7.51e-180: 522: 76.53
+	Hs
		1294943 WNK4_HUMAN (601-866): 1.79e-33: 143: 24.44		KLHL3_HUMAN (1-587): 0: 547: 100.00
+	Hs
		307202 WNK4_HUMAN (601-866): 1.79e-33: 143: 24.44		KLHL2_HUMAN (1-587): 7.51e-180: 522: 76.53