HitPredict

Interactor 1: BCL9 (O00512)
B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)
Gene: BCL9

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1426 Hs			1 359
+	Hs
		131710 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Hs
		131704 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Hs
		131711 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Hs
		131736 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		131749 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		131702 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74
+	Hs
		131726 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX8_HUMAN (7-81): 1.2e-12: 70: 20.00
+	Hs
		131751 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX6_HUMAN (7-81): 1.54e-11: 66.9: 20.00
+	Hs
		899924 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Hs
		1200126 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Hs
		839836 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Hs
		839774 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Hs
		903746 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Hs
		839785 KMT2C_HUMAN (40-881): 1.95e-11: 71.6: 8.19		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Hs
		1281194 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		1350240 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		1200125 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		822688 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74
+	Hs
		1200133 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LHX6_HUMAN (7-81): 1.54e-11: 66.9: 20.00
+	Hs
		822650 KMT2C_HUMAN (40-881): 1.95e-11: 71.6: 8.19		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74