Interactor 1: FNDC5 (Q8K4Z2)
Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) (Peroxisomal protein) (PeP) [Cleaved into: Irisin]
Gene: FNDC5

Interactor 2: IGSF8 (Q8R366)
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocyte-associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
Gene: IGSF8

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 0.90 0.586

The method score is based on:

Property Details
Experiments 30550785
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains V-set~fn3
Common GO terms GO:0005886 - plasma membrane
Homologous interactions 0

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Last updated: 11Aug2025