HitPredict

Interactor 1: ADA33 (Q9BZ11)
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)
Gene: ADAM33

Interactor 2: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 813 Hs			1 2321
+	Hs
		1253280 ADA32_HUMAN (35-805): 3.33e-143: 443: 23.60		NOTC3_HUMAN (43-2321): 0: 1185: 100.00
+	Hs
		980469 ATS15_HUMAN (17-669): 4.02e-111: 363: 18.99		NOTC2_HUMAN (584-1691): 1.87e-117: 419: 26.15
+	Hs
		980569 ATS1_HUMAN (33-672): 3.79e-110: 361: 19.70		NOTC2_HUMAN (584-1691): 1.87e-117: 419: 26.15
+	Hs
		1253281 ADA32_HUMAN (35-805): 3.33e-143: 443: 23.60		JAG2_HUMAN (2-416): 1.8e-37: 157: 26.53
+	Hs
		1356430 ADA30_HUMAN (48-739): 2.61e-134: 420: 28.82		JAG2_HUMAN (2-416): 1.8e-37: 157: 26.53
+	Dm
		422806 Q94902_DROME (298-519): 1.99e-17: 89.4: 29.30		NOTCH_DROME (496-1588): 8.18e-136: 479: 28.34
+	Dm
		422881 Q9VJW9_DROME (298-519): 2e-17: 89.4: 29.30		NOTCH_DROME (496-1588): 8.18e-136: 479: 28.34
+	Mm
		193004 ADA10_MOUSE (154-519): 4.69e-24: 110: 27.73		ANK2_MOUSE (1575-2285): 2.68e-112: 404: 15.78
+	Hs
		980561 ATS9_HUMAN (50-462): 2.65e-17: 89.4: 24.85		NOTC2_HUMAN (584-1691): 1.87e-117: 419: 26.15
+	Dm
		1182372 Q9VJW9_DROME (298-519): 2e-17: 89.4: 29.30		Q7KU92_DROME (1709-2254): 1.88e-109: 395: 16.25
+	Hs
		944116 ADA17_HUMAN (298-583): 2.88e-24: 111: 30.19		JAG1_HUMAN (1109-1532): 2.87e-29: 130: 20.79
+	Dm
		485022 Q94902_DROME (298-519): 1.99e-17: 89.4: 29.30		DL_DROME (42-195): 1.2e-17: 92: 36.54
+	Dm
		485030 Q9VJW9_DROME (298-519): 2e-17: 89.4: 29.30		DL_DROME (42-195): 1.2e-17: 92: 36.54