HitPredict

Interactor 1: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 889 Hs			1 1620
+	Hs
		434280 OSBL8_HUMAN (1-889): 0: 1210: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		445877 OSBL8_HUMAN (1-889): 0: 1210: 100.00		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		508182 OSBL8_HUMAN (1-889): 0: 1210: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411491 OSBL8_HUMAN (1-889): 0: 1210: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435752 OSBL8_HUMAN (1-889): 0: 1210: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		537771 OSBL8_HUMAN (1-889): 0: 1210: 100.00		INSRR_HUMAN (1082-1384): 2.38e-70: 262: 43.46
+	Hs
		385477 OSBL8_HUMAN (1-889): 0: 1210: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		1081595 OSBL8_HUMAN (1-889): 0: 1210: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		537772 OSBL5_HUMAN (32-889): 0: 1012: 54.21		INSRR_HUMAN (1082-1384): 2.38e-70: 262: 43.46
+	Hs
		508159 OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		435736 OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		508177 OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		435750 OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		385387 OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		384259 OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		603057 OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		385465 OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07