HitPredict

Interactor 1: KRIT1 (O00522)
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)
Gene: KRIT1

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 189
+	Hs
		131834 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		131821 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		131826 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		131828 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Hs
		131823 KRIT1_HUMAN (1-736): 6.6e-159: 479: 100.00		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		1021405 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		350123 ANK3_HUMAN (8-558): 6.78e-92: 317: 12.08		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349253 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Mm
		71299 ANR44_MOUSE (5-652): 3.26e-83: 286: 11.33		RAB13_MOUSE (4-188): 2.76e-75: 226: 35.05
+	Hs
		349001 ANR50_HUMAN (19-383): 1.18e-70: 254: 10.29		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		350083 ANK2_HUMAN (5-374): 4.24e-78: 276: 12.53		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350675 ANR50_HUMAN (19-383): 1.18e-70: 254: 10.29		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349155 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348539 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		719496 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		349925 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349416 ANR11_HUMAN (257-404): 5.64e-29: 126: 26.85		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		719572 MERL_HUMAN (487-725): 2.81e-49: 184: 21.67		RIT1_HUMAN (3-176): 8.94e-56: 177: 50.29
+	Dm
		65552 A8JNM5_DROME (5-307): 5.8e-42: 167: 10.20		RALA_DROME (4-182): 3.4e-60: 187: 52.22
+	Dm
		1248518 Q8SWY2_DROME (5-307): 5.46e-37: 151: 10.20		Q962I2_DROME (4-178): 1.03e-60: 189: 51.14