HitPredict

Interactor 1: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20516148
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 628
+	Hs
		537154 TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		1282085 TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		1317554 TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		278162 TRIM5_HUMAN (1-521): 1.5e-74: 246: 14.08		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277914 TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278144 TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278161 TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278189 TRI35_HUMAN (6-289): 6.71e-49: 178: 26.12		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278217 TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278315 TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278333 TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		135032 TRI38_HUMAN (1-517): 4.32e-72: 239: 16.32		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		536921 TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		278302 TRI50_HUMAN (9-252): 3.32e-13: 73.9: 23.36		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		170420 TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71