HitPredict

Interactor 1: DPY30 (Q9C005)
Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)
Gene: DPY30

Interactor 2: KMT2B (Q9UMN6)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 23995757
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044665 - MLL1/2 complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 99 Hs			1 2715
+	Hs
		1318624 DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00		SET1B_HUMAN (1961-2715): 3.45e-66: 252: 23.84
+	Hs
		975318 DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Dm
		1129081 DPY30_DROME (42-99): 1.39e-24: 91.7: 51.72		SET1_DROME (2300-2715): 5.02e-70: 264: 23.25
+	Sp
		252202 SDC1_SCHPO (48-89): 9.88e-13: 60.5: 47.62		SET1_SCHPO (2199-2715): 8.78e-78: 281: 21.44
+	Hs
		165713 DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00		SET1A_HUMAN (2571-2715): 1.52e-26: 122: 52.74
+	Hs
		152687 DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00		KMT2D_HUMAN (396-778): 9.23e-10: 67.2: 20.80
+	Hs
		1243840 DPY30_HUMAN (1-99): 2.56e-50: 155: 100.00		KMT2C_HUMAN (2005-2475): 4.5e-09: 64.8: 11.39