HitPredict

Interactor 1: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 12878161, 18799573, 26212332, 30503508, 11331580, 18312418, 21734049, 16828831, 18799578, 17156811, 16254380, 17543365, 16808955, 22493164, 22829933
Identification Methods enzymatic study, pull down, two hybrid, affinity chromatography technology, biochemical, two hybrid array, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SPRY~SPRY, zf-B_box~zf-B_box, zf-B_box~zf-RING_UBOX, zf-RING_UBOX~zf-RING_UBOX
Common GO terms GO:0000209 - protein polyubiquitination
GO:0000932 - P-body
GO:0002218 - activation of innate immune response
GO:0003713 - transcription coactivator activity
GO:0004842 - ubiquitin-protein transferase activity
and 23 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 493
Hs

1 493
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Last updated: 15 Jul 2024