HitPredict

Interactor 1: WDR33 (Q9C0J8)
pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)
Gene: WDR33

Interactor 2: CPSF2 (Q9P2I0)
Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)
Gene: CPSF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	24981860, 33961781, 35177536
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1336 Hs			1 782
+	Hs
		1319421 WDR33_HUMAN (1-1324): 2.65e-176: 561: 96.13		CPSF3_HUMAN (2-558): 1.85e-173: 516: 21.28
+	At
		1154739 FY_ARATH (15-615): 6.63e-95: 321: 39.08		CPSF2_ARATH (1-782): 0: 714: 36.89
+	Hs
		903574 WDR5_HUMAN (367-521): 5.01e-11: 67.7: 10.97		CPSF2_HUMAN (1-782): 0: 952: 100.00
+	At
		1154737 FY_ARATH (15-615): 6.63e-95: 321: 39.08		CPSF3_ARATH (2-576): 4.63e-174: 518: 19.97
+	Sc
		791188 PFS2_YEAST (49-409): 2.05e-111: 360: 38.80		CFT2_YEAST (1-780): 7.18e-156: 477: 20.61
+	Sc
		791183 PFS2_YEAST (49-409): 2.05e-111: 360: 38.80		YSH1_YEAST (2-538): 1.74e-145: 447: 21.07
+	At
		1154736 FY_ARATH (15-615): 6.63e-95: 321: 39.08		CPS3B_ARATH (4-567): 3.84e-160: 480: 19.10
+	Hs
		1281466 FBXW7_HUMAN (229-428): 7.22e-42: 167: 21.89		CPSF3_HUMAN (2-558): 1.85e-173: 516: 21.28
+	Hs
		793039 LIS1_HUMAN (284-476): 1.35e-37: 148: 18.65		CPSF3_HUMAN (2-558): 1.85e-173: 516: 21.28
+	Sp
		142965 PFS2_SCHPO (24-287): 2.97e-41: 162: 14.53		YSH1_SCHPO (2-540): 3.17e-158: 480: 21.28