HitPredict

Interactor 1: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Interactor 2: CBX8 (Q9QXV1)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (mPc3)
Gene: CBX8

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	17296600, 16359901
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 336 Mm			1 362
+	Mm
		1164651 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		Q6TKP2_MOUSE (1-360): 2.41e-95: 299: 33.91
+	Hs
		1304116 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX8_HUMAN (1-362): 1.14e-93: 286: 87.15
+	Mm
		1321737 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		CBX6_MOUSE (1-359): 4.06e-86: 268: 34.48
+	Hs
		316133 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX6_HUMAN (1-359): 5.08e-70: 226: 33.42
+	Mm
		193417 RING1_MOUSE (10-336): 8.61e-69: 222: 52.00		CBX8_MOUSE (1-362): 7.74e-103: 309: 100.00
+	Mm
		675501 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		CBX2_MOUSE (2-330): 3.34e-58: 198: 22.34
+	Dr
		1193367 RING2_DANRE (1-336): 1.86e-103: 308: 89.29		Q804D1_DANRE (1-328): 5.51e-60: 202: 22.41
+	Hs
		1059184 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX2_HUMAN (2-330): 3.12e-55: 191: 22.62
+	Hs
		327858 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX7_HUMAN (1-224): 1.89e-43: 152: 30.83
+	Mm
		223231 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		CBX4_MOUSE (1-318): 2.91e-39: 148: 24.28
+	Hs
		123308 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX4_HUMAN (1-322): 8.78e-39: 147: 22.50
+	Hs
		316019 RING1_HUMAN (10-336): 3.44e-66: 215: 51.75		CBX6_HUMAN (1-359): 5.08e-70: 226: 33.42
+	Mm
		1257537 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		CBX7_MOUSE (1-86): 2.14e-30: 115: 61.63
+	Mm
		193405 RING1_MOUSE (10-336): 8.61e-69: 222: 52.00		CBX2_MOUSE (2-330): 3.34e-58: 198: 22.34
+	Mm
		1321739 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		Q9DCC5_MOUSE (9-104): 3.84e-24: 99.4: 33.33
+	Mm
		613033 RING2_MOUSE (1-336): 2.13e-106: 316: 100.00		CBX3_MOUSE (9-104): 4.76e-24: 99.4: 32.29
+	Hs
		1027216 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX3_HUMAN (9-104): 3.84e-24: 99.4: 33.33
+	Hs
		949867 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		CBX1_HUMAN (17-76): 8.73e-21: 90.5: 40.00
+	Hs
		123243 RING1_HUMAN (10-336): 3.44e-66: 215: 51.75		CBX4_HUMAN (1-322): 8.78e-39: 147: 22.50
+	Mm
		193412 RING1_MOUSE (10-336): 8.61e-69: 222: 52.00		CBX7_MOUSE (1-86): 2.14e-30: 115: 61.63