HitPredict

Interactor 1: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	17296600
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000278 - mitotic cell cycle GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031519 - PcG protein complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 336 Mm			1 163
+	Hs
		929043 RING2_HUMAN (1-336): 2.74e-106: 315: 99.70		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		928883 RING1_HUMAN (10-336): 3.44e-66: 215: 51.75		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929051 PCGF6_HUMAN (30-293): 1.72e-44: 157: 15.36		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		717667 BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		928932 PCGF3_HUMAN (36-334): 2.56e-43: 151: 17.16		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		718386 PCGF2_HUMAN (34-332): 3.57e-40: 145: 15.51		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		928968 PCGF5_HUMAN (34-334): 2.53e-39: 141: 18.24		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		584925 RO52_HUMAN (36-249): 1.63e-36: 139: 13.08		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Dm
		285038 Q9VV77_DROME (36-334): 4.84e-45: 155: 18.69		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Hs
		749352 BRCA1_HUMAN (36-213): 1.88e-33: 132: 25.93		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929047 PCGF1_HUMAN (28-336): 1.37e-35: 131: 16.56		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Zm
		27602 A0A1D6M7Z6_MAIZE (41-215): 2.27e-12: 70: 20.00		A0A1D6JK98_MAIZE (4-156): 8.86e-50: 164: 30.07