HitPredict

Interactor 1: FXL20 (Q9CZV8)
F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)
Gene: Fbxl20

Interactor 2: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	17803915
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 436 Mm			1 776
+	Hs
		1041146 FXL20_HUMAN (1-436): 1.72e-94: 292: 99.77		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041267 FBXL2_HUMAN (14-436): 2.83e-82: 261: 77.78		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041091 FBXL6_HUMAN (21-421): 4.4e-46: 168: 20.69		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041256 FBXL7_HUMAN (194-436): 3.65e-32: 129: 26.09		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041265 FBXL4_HUMAN (145-436): 5.64e-27: 115: 20.40		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041088 FXL14_HUMAN (166-435): 5.17e-24: 105: 25.89		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041248 FXL17_HUMAN (224-436): 6.17e-19: 91.5: 23.83		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1031190 SKP2_HUMAN (28-280): 6.7e-15: 78.2: 28.94		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041495 FBXL2_HUMAN (14-436): 2.83e-82: 261: 77.78		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		1041552 SCRIB_HUMAN (137-436): 1.63e-30: 126: 12.87		CUL3_HUMAN (9-776): 0: 749: 30.47
+	At
		1277335 AFB3_ARATH (28-406): 8.97e-37: 143: 20.25		CUL1_ARATH (10-776): 0: 722: 30.29
+	Hs
		1031192 SKP2_HUMAN (28-280): 6.7e-15: 78.2: 28.94		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	At
		1173680 EBF2_ARATH (39-435): 9.3e-33: 132: 22.30		CUL1_ARATH (10-776): 0: 722: 30.29
+	At
		1123013 TIR1_ARATH (21-408): 1.78e-32: 131: 18.78		CUL1_ARATH (10-776): 0: 722: 30.29
+	At
		221522 SKP2B_ARATH (222-408): 1.06e-30: 123: 25.79		CUL1_ARATH (10-776): 0: 722: 30.29
+	At
		1277350 GRH1_ARATH (26-419): 9.05e-29: 120: 18.75		CUL1_ARATH (10-776): 0: 722: 30.29
+	Hs
		1042760 FXL17_HUMAN (224-436): 6.17e-19: 91.5: 23.83		CUL3_HUMAN (9-776): 0: 749: 30.47
+	At
		1277334 SKP2A_ARATH (249-416): 4.91e-25: 107: 28.66		CUL1_ARATH (10-776): 0: 722: 30.29
+	Hs
		1031191 SKP2_HUMAN (28-280): 6.7e-15: 78.2: 28.94		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Sc
		624323 GRR1_YEAST (91-274): 2.31e-18: 89.8: 21.39		CDC53_YEAST (13-776): 0: 629: 31.36