HitPredict

Interactor 1: DLL1 (O00548)
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)
Gene: DLL1

Interactor 2: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 11006133
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DSL~EGF_CA, EGF~EGF, EGF~EGF_CA, EGF_CA~MNNL
Common GO terms GO:0001947 - heart looping
GO:0002085 - inhibition of neuroepithelial cell differentiation
GO:0005112 - Notch binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
and 16 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 723
Hs

1 2555
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024