HitPredict

Interactor 1: CAC1A (O00555)
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)
Gene: CACNA1A

Interactor 2: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21078624
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001540 - amyloid-beta binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016020 - membrane GO:1904646 - cellular response to amyloid-beta
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2506 Hs			1 4544
+	Hs
		992715 SCN3A_HUMAN (648-986): 1.23e-11: 72.8: 15.50		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Dm
		422755 CAC1D_DROME (1194-1544): 1.16e-38: 162: 22.79		NOTCH_DROME (2434-2789): 1.13e-10: 70.6: 11.72
+	Hs
		957650 SCN3A_HUMAN (648-986): 1.23e-11: 72.8: 15.50		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		1048456 SCN3A_HUMAN (648-986): 1.23e-11: 72.8: 15.50		LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54