HitPredict

Interactor 1: CAC1A (O00555)
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)
Gene: CACNA1A

Interactor 2: NELL2 (Q99435)
Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)
Gene: NELL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21078624
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2506 Hs			1 816
+	Hs
		132338 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		NELL1_HUMAN (19-812): 1.47e-99: 329: 55.53
+	Hs
		126309 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		MATN2_HUMAN (486-795): 1.72e-24: 112: 21.02
+	Hs
		132314 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		LTBP1_HUMAN (478-788): 2.94e-22: 105: 21.26
+	Hs
		132298 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		NOTC1_HUMAN (167-649): 2.93e-21: 102: 13.36
+	Hs
		132308 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		FBLN3_HUMAN (432-628): 2.41e-20: 97.1: 34.12
+	Hs
		132290 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		FBLN1_HUMAN (401-628): 3.37e-19: 94.7: 35.22
+	Hs
		132331 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		LTBP4_HUMAN (287-632): 1.81e-18: 92.9: 18.62
+	Hs
		132361 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		JAG2_HUMAN (510-816): 4.42e-10: 65.7: 15.26
+	Hs
		132280 CAC1A_HUMAN (1-2506): 0: 1897: 100.00		FBLN4_HUMAN (413-509): 4.29e-09: 61.6: 37.11
+	Hs
		1047225 CAC1C_HUMAN (1129-1934): 1.84e-95: 348: 18.82		NELL2_HUMAN (1-816): 4.02e-126: 399: 100.00
+	Hs
		1047190 CAC1C_HUMAN (1129-1934): 1.84e-95: 348: 18.82		NELL1_HUMAN (19-812): 1.47e-99: 329: 55.53
+	Hs
		1016946 CAC1C_HUMAN (1129-1934): 1.84e-95: 348: 18.82		FBLN3_HUMAN (432-628): 2.41e-20: 97.1: 34.12
+	Hs
		434646 CAC1C_HUMAN (1129-1934): 1.84e-95: 348: 18.82		TSP1_HUMAN (199-741): 5.64e-09: 61.9: 11.05
+	Mm
		723642 CAC1C_MOUSE (1126-1515): 2.46e-30: 134: 18.67		TSP1_MOUSE (30-768): 1.76e-44: 175: 15.67
+	Dm
		422755 CAC1D_DROME (1194-1544): 1.16e-38: 162: 22.79		NOTCH_DROME (167-571): 2.91e-11: 69.6: 8.74
+	Hs
		723854 SCN4A_HUMAN (1521-1746): 2.5e-23: 111: 17.75		AGRE5_HUMAN (380-514): 9.87e-20: 96.7: 33.57