HitPredict

Interactor 1: M2K6 (Q9FJV0)
Mitogen-activated protein kinase kinase 6 (AtMKK6) (MAP kinase kinase 6) (EC 2.7.12.2) (Protein Arabidopsis NQK1 homolog)
Gene: MKK6

Interactor 2: MPK13 (Q9LQQ9)
Mitogen-activated protein kinase 13 (AtMPK13) (MAP kinase 13) (EC 2.7.11.24)
Gene: MPK13

Species: Arabidopsis thaliana

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	20802223, 21575092, 19513235, 15474000
Identification Methods	two hybrid, protein complementation assay, experimental interaction detection
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0010311 - lateral root formation GO:0016310 - phosphorylation GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 356 At			1 363
+	At
		1106354 M2K6_ARATH (1-356): 1.24e-129: 376: 100.00		MPK4_ARATH (2-362): 1.26e-162: 461: 72.85
+	At
		1106332 M2K1_ARATH (5-354): 1.89e-126: 368: 53.54		MPK4_ARATH (2-362): 1.26e-162: 461: 72.85
+	At
		1106388 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK4_ARATH (2-362): 1.26e-162: 461: 72.85
+	At
		1323812 M2K6_ARATH (1-356): 1.24e-129: 376: 100.00		MPK11_ARATH (4-362): 1.18e-155: 443: 71.87
+	At
		1106594 M2K6_ARATH (1-356): 1.24e-129: 376: 100.00		MPK6_ARATH (11-362): 4.2e-153: 437: 66.76
+	At
		1277206 M2K1_ARATH (5-354): 1.89e-126: 368: 53.54		MPK11_ARATH (4-362): 1.18e-155: 443: 71.87
+	At
		1338614 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK11_ARATH (4-362): 1.18e-155: 443: 71.87
+	At
		1339243 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK13_ARATH (1-363): 8.95e-156: 443: 100.00
+	At
		1106499 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK5_ARATH (1-363): 5.43e-154: 439: 71.07
+	At
		1106648 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK6_ARATH (11-362): 4.2e-153: 437: 66.76
+	At
		1210051 M2K6_ARATH (1-356): 1.24e-129: 376: 100.00		MPK12_ARATH (11-362): 8.36e-149: 426: 66.76
+	At
		1210050 M2K1_ARATH (5-354): 1.89e-126: 368: 53.54		MPK12_ARATH (11-362): 8.36e-149: 426: 66.76
+	At
		1259060 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK16_ARATH (1-362): 6.24e-147: 428: 43.90
+	At
		1340915 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK10_ARATH (8-362): 4.04e-148: 425: 63.10
+	Mm
		554917 KPCE_MOUSE (3-356): 2.28e-128: 386: 20.54		MK03_MOUSE (22-362): 7.28e-140: 404: 50.15
+	Hs
		116999 SGK1_HUMAN (1-355): 1.57e-126: 371: 21.27		MK07_HUMAN (20-361): 1.98e-139: 417: 49.71
+	Hs
		658893 KPCE_HUMAN (3-356): 9.13e-128: 384: 20.54		MK01_HUMAN (32-362): 2.37e-140: 404: 51.64
+	Rn
		448414 KPCE_RAT (3-356): 1.45e-126: 381: 20.81		MK01_RAT (32-362): 2.21e-140: 404: 51.64
+	Hs
		568646 KAPCA_HUMAN (58-355): 2.17e-126: 368: 24.26		MK07_HUMAN (20-361): 1.98e-139: 417: 49.71
+	At
		1106733 M2K2_ARATH (8-344): 1.21e-125: 366: 56.51		MPK7_ARATH (7-362): 2.34e-143: 412: 54.90