HitPredict

Interactor 1: MLP3B (Q9GZQ8)
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)
Gene: MAP1LC3B

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	21617041, 33545068, 37219487
Identification Methods	pull down, proximity labelling technology, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 125 Hs			1 729
+	Hs
		1330656 MLP3A_HUMAN (1-120): 8.21e-55: 168: 82.50		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		1254138 MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		306242 GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		891314 GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47		SIK2_HUMAN (9-719): 1.2e-110: 359: 15.54
+	Hs
		1254139 GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		262316 MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		1223630 MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00		ULK2_HUMAN (13-222): 2.85e-25: 114: 33.80
+	Hs
		262319 MLP3A_HUMAN (1-120): 8.21e-55: 168: 82.50		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		262249 GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		262209 GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		891216 GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47		ULK2_HUMAN (13-222): 2.85e-25: 114: 33.80
+	Hs
		262314 MLP3C_HUMAN (1-120): 2.08e-51: 161: 55.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		262317 GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		306230 GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30		ULK2_HUMAN (13-222): 2.85e-25: 114: 33.80
+	Hs
		1223631 GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46		ULK2_HUMAN (13-222): 2.85e-25: 114: 33.80
+	Dm
		1228782 Q9W2S2_DROME (7-122): 5.18e-54: 166: 31.03		Q8MQJ7_DROME (13-221): 1.89e-21: 101: 31.65
+	Ce
		999349 LGG1_CAEEL (6-120): 5.55e-51: 159: 33.04		UNC51_CAEEL (13-221): 9.3e-22: 102: 32.88