HitPredict

Interactor 1: EGLN1 (Q9GZT9)
Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)
Gene: EGLN1

Interactor 2: EGLN3 (Q9H6Z9)
Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
Gene: EGLN3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

The method score is based on:

Property	Details
Experiments	31763849, 16958618
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	2OG-FeII_Oxy_3~2OG-FeII_Oxy_3
Common GO terms	GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008198 - ferrous iron binding and 6 others more... GO:0016706 - 2-oxoglutarate-dependent dioxygenase activity GO:0018401 - peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0031418 - L-ascorbic acid binding GO:0031545 - peptidyl-proline 4-dioxygenase activity GO:0071456 - cellular response to hypoxia GO:0160082 - hypoxia-inducible factor-proline dioxygenase activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	426
Hs

1	239

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024