HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38280479
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 1235
+	Hs
		808919 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		SLK_HUMAN (1-1235): 0: 720: 100.00
+	Mm
		809064 YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30		CTRO_MOUSE (8-1230): 4.45e-138: 465: 16.06
+	Hs
		808570 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		PAK2_HUMAN (7-305): 1.42e-110: 358: 36.79
+	Hs
		149028 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		148925 MAGI3_HUMAN (3-246): 4.83e-43: 162: 19.28		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		149188 MAGI1_HUMAN (10-212): 9.04e-40: 153: 15.74		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		883230 ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83		SIK1_HUMAN (25-604): 3.59e-130: 420: 17.29
+	Hs
		1027424 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		STK3_HUMAN (30-307): 1.02e-62: 224: 43.42
+	Hs
		808801 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		MYO3B_HUMAN (29-292): 4.17e-61: 231: 43.22
+	Hs
		1027416 ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83		STK3_HUMAN (30-307): 1.02e-62: 224: 43.42
+	Hs
		1336133 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		M4K5_HUMAN (29-292): 6.48e-62: 230: 44.74
+	Hs
		1336112 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		TNIK_HUMAN (29-323): 5.68e-55: 212: 40.59
+	Hs
		1023111 SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	Hs
		1027431 SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89		STK3_HUMAN (30-307): 1.02e-62: 224: 43.42
+	Mm
		1257562 SAV1_MOUSE (2-252): 2.39e-46: 165: 15.89		STK4_MOUSE (30-307): 5.67e-63: 224: 44.09
+	Dm
		1115138 YAP1_DROME (17-223): 5.05e-46: 164: 22.80		HIPPO_DROME (30-314): 3.52e-61: 224: 41.05
+	Dm
		1249840 KIBRA_DROME (122-260): 5.04e-43: 162: 21.58		HIPPO_DROME (30-314): 3.52e-61: 224: 41.05
+	Hs
		1220095 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		TNIK_HUMAN (29-323): 5.68e-55: 212: 40.59
+	Hs
		1356405 WWC3_HUMAN (119-258): 4.68e-41: 156: 18.57		TNIK_HUMAN (29-323): 5.68e-55: 212: 40.59
+	Hs
		1035209 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		ROCK1_HUMAN (796-1223): 6.3e-17: 88.9: 11.01