HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25670202
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0035329 - hippo signaling GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 1088
+	Hs
		808960 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Mm
		809076 YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30		LATS2_MOUSE (1-1088): 0: 876: 80.66
+	Hs
		1220087 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1330812 SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1149656 WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		325883 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Mm
		1207482 WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00		LATS1_MOUSE (1-1082): 0: 735: 49.61
+	Hs
		325656 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325886 WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325853 ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		125071 WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325898 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325797 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325888 SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325775 WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		1336122 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Hs
		1069657 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		568765 ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Dm
		1115141 YAP1_DROME (17-223): 5.05e-46: 164: 22.80		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Hs
		1035209 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77