HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: SHAN1 (Q9Y566)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
Gene: SHANK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 2161
+	Hs
		809057 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		SHAN1_HUMAN (1-2161): 4.7e-149: 516: 100.00
+	Hs
		862101 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		DAPK1_HUMAN (221-642): 6.21e-61: 233: 13.90
+	Hs
		1021456 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Hs
		125583 WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46		ANR44_HUMAN (6-512): 1.73e-91: 323: 14.94
+	Hs
		276153 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		PSD10_HUMAN (222-419): 8.16e-65: 222: 28.36
+	Hs
		808564 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Hs
		1326761 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		RAI14_HUMAN (182-406): 1.78e-14: 81.6: 29.20
+	Hs
		125054 WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46		PSD10_HUMAN (222-419): 8.16e-65: 222: 28.36
+	Hs
		1336115 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		ANR50_HUMAN (8-319): 3.8e-64: 244: 15.92
+	Hs
		808975 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		RAI14_HUMAN (182-406): 1.78e-14: 81.6: 29.20
+	Hs
		808109 NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Hs
		1316279 WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Hs
		1176346 HECW1_HUMAN (14-327): 1.21e-53: 194: 14.29		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Mm
		1116041 HECW1_MOUSE (14-327): 1.64e-51: 187: 13.76		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Mm
		1116029 NED4L_MOUSE (129-395): 4.63e-24: 106: 11.96		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Mm
		93271 E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Mm
		808351 NEDD4_MOUSE (129-328): 8.42e-21: 96.6: 10.44		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Hs
		1349044 WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09		ANKR6_HUMAN (165-266): 5.59e-12: 73.4: 19.61