HitPredict

Interactor 1: SHRPN (Q9H0F6)
Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)
Gene: SHARPIN

Interactor 2: NOD2 (Q9HC29)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
Gene: NOD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26670046, 22607974, 23818254
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043130 - ubiquitin binding GO:0044877 - protein-containing complex binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 387 Hs			1 1040
+	Hs
		1317085 HOIL1_HUMAN (171-379): 1.86e-103: 316: 43.67		NOD2_HUMAN (1-1040): 0: 884: 100.00